CPS-IoT Week is the premier event on Cyber-Physical Systems and Internet-of-Things Research. It brings together four conferences, HSCC, ICCPS, IPSN and RTAS, and multiple workshops, tutorials, competitions and various exhibitions from both industry and academia. Altogether the CPS-IoT Week program covers a multitude of complementary aspects of CPS and IoT, and reunites the leading researchers in this dynamic field. The 2022 edition of the event will be held in Milan, Italy.